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秦四勇导师概况
秦四勇导师概况


姓名:秦四勇

职称:副教授

单位:威尼斯手机网站

学科专业:材料化学

研究方向:生物医用材料、小分子自组装

学者概况:

秦四勇(1985-),男,博士,副教授,硕士生导师。2009年毕业于黄冈师范学院,获化学专业学士学位;2009年至2014年在武汉大学硕博连读,师从卓仁禧院士和张先正教授,获高分子化学与物理专业博士学位。20147-20153月在贵州大学材料与冶金学院工作,于20154月加入到威尼斯手机网站。主要从事小分子肽以及抗癌药等自组装构建微、纳米材料及其在生物医学方面的应用。在Biomaterials, Small, Chem. Commun., Nanoscale, Nano Research等国际期刊公开发表SCI论文40余篇。曾获得教育部武汉大学博士学术新人奖、湖北省优秀博士学位论文、研究生国家奖学金、武汉大学学术创新奖一等奖/二等奖、武汉大学优秀毕业生等荣誉。2017年在Biomaterials发表论文(Drug self-delivery systems for cancer therapy)为ESI高被引论文。


主持的主要研究项目

  1. 国家自然科学基金青年基金项目,51503227,功能聚合物改性的新型寡肽凝胶的构建及其生物医用研究

  2. 湖北省自然科学基金一般面上项目,2017CFB528,基于叶酸和甲氨蝶呤的复合自运载体系用于癌症靶向治疗。

  3. 功能材料绿色制备与应用教育部重点实验室2017年开放课题,聚集诱导发光材料的合成及其用于癌症诊疗研究。

  4. 中南民族大学基本科研业务费专项资金项目,功能肽和聚合物共修饰的纳米药物体系用于癌症靶向治疗。

  5. 武汉大学化学与分子科学学院全国百篇优秀博士学位论文培育计划,环肽自组装行为的研究及其生物医学研究。

  6. 2012年度博士研究生学术新人奖,5052012203003,基于多肽和聚乙烯亚胺修饰的石墨烯载体用于细胞癌变的荧光检测与治疗。

  7. 武汉大学研究生学生自主科研项目,2012203020201,基于酶敏感的石墨烯多肽交联体的双功能细胞识别器。

代表论文

  1. Qin, Si-Yong,* Ding, Wen-Qiang, Jiang, Zhiwei, Lei, Xinxiang,* Zhang, Ai-Qing,* Directing oligopeptide amphiphile into aligned nanofiber matrix for elucidating molecular structures.Chem. Commun., 2019, 55, 1659-1662.

  2. Qin, Si-Yong, Zhang, Ai-Qing, and Zhang, Xian-Zheng*, Recent Advances in Targeted Tumor Chemotherapy Based on Smart Nanomedicines, Small, 2018, 1802417.

  3. Ding, Wen-Qiang, Qin, Si-Yong*, Cheng, Yin-Jia, Ma, Yi-Han, Zhang, Ai-Qing*. Novel oligopeptide nanoprobe for targeted cancer cell imaging,RSC Adv., 2018, 8, 30887–30893.

  4. Rong, Lei#,Qin, Si-Yong#, Zhang, Chi, Cheng, Yin-Jia, Feng, Jun, Wang, Shi-Bo, Zhang, Xian-Zheng*, Biomedical applications of functional peptides in nano-systems,Materials Today Chemistry, 2018, 9, 91-102.

  5. Qin, Si-Yong, Cheng, Yin-Jia, Lei, Qi, Zhang, Ai-Qing, Zhang, Xian-Zheng*, Combinational strategy for high-performance cancer chemotherapy, Biomaterials, 2018, 112,178-197.

  6. Qin, Si-Yong?, Cheng, Yin-Jia, Jiang, Zhi-Wei, Ma, Yi-Han, Zhang, Ai-Qing.*Morphology control of self-deliverable nanodrug with enhanced anticancer efficiency, Colloids and Surfaces B: Biointerfaces, 2018, 165: 345-354.

  7. Zhang, Chen-Ming, Qin, Si-Yong*, Cheng, Yin-Jia, Zhang, Ai-Qing*.Construction of poly(dopamine) doped oligopeptide hydrogel.RSC Adv., 2017, 7, 50425–50429.

  8. Qin, Si-Yong, Zhang, Ai-Qing, Cheng, Si-Xue, Rong, Lei, Zhang, Xian-Zheng*.Combinational strategy for high-performance cancer chemotherapy, Biomaterials, 2017, 112, 234-247.

  9. Peng, Meng Yun#, Qin, Si-Yong#, Jia, Hui-Zhen, Zheng, Di-Wei, Rong, Lei, Zhang, Xian-Zheng*. Self-delivery of peptide based prodrug for tumor targeting therapy. Nano Research, 2016, 9, 663-673.

  10. Qin, Si-Yong, Peng, Meng-Yun, Rong, Lei, Jia, Hui-Zhen, Chen, Si, Cheng, Si-Xue, Feng, Jun, Zhang, Xian-Zheng*. An innovative pre-targeting strategy for tumor cell specific imagingand therapy. Nanoscale, 2015, 7, 14786-14793.

  11. Qin, Si-Yong, Peng, Meng-Yun, Rong, Lei, Li, Bin, Wang, Shi-Bo, Cheng, Si-Xue, Zhuo, Ren-Xi, Zhang, Xian-Zheng*.Self-defensive nano-assemblies from camptothecin-based antitumor drugs. Regenerative Biomaterials, 2015, 2, 159-166.

  12. Qin, Si-Yong#, Jiang, Hua-Fang#, Peng, Meng-Yun, Lei, Qi, Zhuo, Ren-Xi, Zhang, Xian-Zheng*. Adjustable nanofibers self-assembled from an irregular conformational peptide amphiphile. Polymer Chemistry, 2015, 6, 519-524.

  13. Qin, Si-Yong, Peng, Meng-Yun, Zhang, Xian-Zheng*, Zhuo, Ren-Xi.Research progress of nanomaterials self-assembled from oligopeptides. Sci China Ser B. 2015, 45, 124-138.

  14. Qin, Si-Yong#, Feng, Jun#, Rong, Lei, Jia, Hui-Zhen, Chen, Si, Liu, Xiang-Ji, Luo, Guo-Feng, Zhuo, Ren-Xi, Zhang, Xian-Zheng*. Theranostic GO-based nanohybrid for tumor induced imaging and potential combinational tumor therapy. Small, 2014, 10, 599-608.

  15. Qin, Si-Yong, Jiang, Hua-Fang, Liu, Xiang-Ji, Pei, Yi, Cheng, Han*, Sun, Yun-Xi, Zhang, Xian-Zheng*. High length-diameter ratio nanotubes self-assembled from a facial cyclopeptide. Soft Matter, 2014, 10, 947-951.

  16. Qin, Si-Yong, Wang, Qing-Rong, Pei, Yi, Peng, Meng-Yun, Zhuo, Ren-Xi, Zhang, Xian-Zheng*. Novel cyclopeptide bolaamphiphile for constructing supramolecular nanotubes. Chinese Journal of Chemistry, 2014, 32, 22-26.

  17. Qin, Si-Yong, Pei, Yi, Liu, Xiang-Ji, Zhuo, Ren-Xi, Zhang, Xian-Zheng*. Hierarchical self-assembly of a beta-amyloid peptide derivative. Journal of Materials Chemistry B, 2013, 1, 668-675.

  18. Qin, Si-Yong, Xu, Sheng-Sheng, Zhuo, Ren-Xi, Zhang, Xian-Zheng*. Morphology transformation via pH-triggered self-assembly of peptides. Langmuir, 2012, 28, 2083-2090.

  19. Qin, Si-Yong, Liu, Xiang-Ji, Zhuo, Ren-Xi, Zhang, Xian-Zheng*. Microstructure-controllable graphene oxide hydrogel film based on a ph-responsive graphene oxide hydrogel. Macromolecular Chemistry and Physics, 2012, 213, 2044-2051.

  20. Qin, Si-Yong, Xu, Xiao-Ding, Chen, Chang-Sheng, Chen, Jing-Xiao, Li, Ze-Yong, Zhuo, Ren-Xi, Zhang, Xian-Zheng*. Supramolecular architectures self-assembled from asymmetrical hetero cyclopeptides. Macromolecular Rapid Communications, 2011, 32, 758-764.

  21. Qin, Si-Yong, Chu, Yan-Feng, Tao, Li, Xu, Sheng-Sheng, Li, Ze-Yong, Zhuo, Ren-Xi, Zhang, Xian-Zheng*. Controllable micro/nanostructures via hierarchical self-assembly of cyclopeptides. Soft Matter, 2011, 7, 8635-8641.


    通讯地址:武汉市洪山区民族大道182

    E-mailsy-qin@mail.scuec.edu.cn; syqinwhu@163.com





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