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Forum: Asymmetric Synthesis of Heterocycles via Organocatalytic Cascade Reactions
发布时间:2019-05-05 浏览次数:


         Professor T?nis Kanger was invited to visit our collegeand give a lecture entitled “Asymmetric synthesis of heterocycles via organocatalytic cascade reactions” at the conference hall of the College of Chemistry and Materials Scienceon Oct. 23, 2018.

          Professor T?nis Kanger is a Dean of Faculty of Science, Tallinn University of Technology from 2010. He got many awards such as Synthesis Best Paper Award (2017), National Research Award in chemistry and molecular biology, Estonia (2016), Science Prize of Estonian Republic(2004). His current research interests include organocatalysis, asymmetric synthesis, and heterocyclic chemistry. He is a head of several research grants and author of 88 publications having the h index of 18.

Past decades have seen remarkable advances in organocatalysis. A simple handling, commercial availability of the chiral catalysts, and non-inert reaction conditions have made the method widely used in asymmetric organic synthesis. Various modes of activation used in organocatalysis are often complementary leading to cascade reactions and providing the molecular complexity from simple starting materials in one step. The lecture covered his research activities in this field. An asymmetric synthesis of trisubstituted piperidine, oxindole and pyran derivatives was discussed. An aminocatalytic and hydrogen bond catalyzed double or triple cascade reactions were used to achieve the targets. Several tertiary or quaternary stereogenic centres are formed in the course of the reaction in highly enantioselective manner.

At the end of lecture, the faculty members and students had intensive discussion on the lecture content with Professor T?nis Kanger. Professor T?nis Kangercomprehensively answered the questions with his extensive scientific knowledge and research experience


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