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Chemistry & Materials Forum No.152: Proteomic music from biological noise (Prof. Pierre Thibault)
发布时间:2019-10-31 浏览次数:

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Prof. Pierre Thibault from the Institute of immunology andcancer, University of Montreal, was invited to have scientific exchange at our College of Chemical and Materials Science and gave a talk on 'Proteomicmusic from biological noise' at Academic Exchange Centeron Oct. 29th, 2019. It was hosted by prof. Xian Wang.

Prof. Thibault presented the structure, design and principle of FAIMS and its application in targeted and non-targeted proteomics. The advantages of ESI-FAIMS compared with conventional ESI-MS was introduced from the point of view of sample complexity and FAIMS principle. The differences between LC-FAIMS and traditional LC-MS methods were compared by proteomic analysis system. He explained the application of TMT marker assisted LC-FAIMS-MS in the analysis of protein abundance in AML cell lines and the quantitative analysis of specific protein in AML patients. He also introduced the analysis of the dynamic changes ofphosphorylated modified protein content in human kidney cells under the stimulation of temperature change by using SILAC marker assisted LC-FAIMS-MS. The talk was welcomed by faculties and students and invited dicussion.

Prof. Pierre Thibault is a renowned bioanalytical chemist specialized in mass spectrometry and proteomics with more than 25 years experience as a principal investigator in academic, government and industry laboratories. Before joining IRIC in 2004, Dr. Thibault was a founding director at Caprion Pharmaceuticals (2001-2004) where he developed an innovative proteomics platform together with bioinformatic tools to identify and quantify proteins differentially expressed in cancer cells aspart of immunotherapy programs in partnership with pharmaceutical companies. He was also a Senior Research Officer with the National Research Council ofCanada’s Institute of Marine Biosciences in Halifax (1990-1996) and Instituteof Biological Sciences in Ottawa (1996-2002). He pioneered the use of sensitive high resolution separation methods and microfluidic devices coupled to massspectrometry and their applications in protein chemistry and cell biology. His current research program in mass spectrometry-based proteomics provides adeeper understanding of molecular mechanisms and post-translational modifications, which regulate the function and translocation of proteins involved in immunity and signalling in cancer cells. His scientific achievements in this area have been recognized by numerous awards and distinctions including most recently the 2019 CSMS Fred Lossing award, 2018 ACFAS Urgel Archambault award and the 2017 Tony Pawson CNPN award. He authored more than 240 publications in scientific journals including Cell, Nature, and Nature medicine. He is editor of the journal Rapid Communications in MassSpectrometry and Molecular & Cellular Proteomics.


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